Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

Study Counts

Type Study_count
Total_Studies 148
interventional 134
Observational 11
Registry 3

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Device 45
Drug 34
Drug|placebo 34
Behavioral 6
Other 5
Device|Other 2
Drug|Procedure 2
Behavioral|Device|Drug 1
Behavioral|Other 1
Device|Drug 1
Device|Drug|placebo 1
Dietary Supplement 1
Other|Procedure 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country Study_Count
United States 73
Canada 13
Germany 6
China 4
France 4
Taiwan 3
United States|Canada 3
Austria 2
Pakistan 2
Australia 1
Belgium 1
Belgium|Germany|Poland 1
Brazil 1
Brazil|United States|Belgium|Bulgaria|Finland|France|Lithuania|Poland|South Africa|Spain|Sweden|United Kingdom 1
Denmark 1
France|Germany|Finland|United States|Argentina|Australia|Austria|Belgium|Brazil|Bulgaria|Korea, Republic of|Lithuania|Malaysia|Mexico|Poland|South Africa|Spain|Sweden|Taiwan|Turkey|United Kingdom 1
Germany|Australia|Austria|Belgium|Bulgaria|Denmark|Hungary|Italy|Portugal|Romania|Slovakia|Spain|United Kingdom 1
Japan 1
Mexico 1
NA 1
Norway 1
Poland 1
Spain 1
United Kingdom 1
United States|Argentina|Australia|Austria|Belgium|Brazil|Bulgaria|Canada|Czechia|Estonia|Finland|France|Germany|Hungary|Italy|Korea, Republic of|Lithuania|Malaysia|Mexico|Poland|Slovakia|Turkey|South Africa|Spain|Sweden|Taiwan|United Kingdom 1
United States|Argentina|India|Mexico|Puerto Rico|Russian Federation|South Africa|Turkey 1
United States|Belgium|Brazil|Canada|Czechia|Estonia|France|Germany|Hungary|Mexico|Poland|Slovakia|Spain|Sweden|Turkey 1
United States|Belgium|Brazil|Canada|Estonia|France|Hungary|Mexico|Slovakia 1
United States|Belgium|Japan 1
United States|Canada|Czechia|Denmark|Ireland|Netherlands|Portugal|Spain|United Kingdom 1
United States|China 1
United States|Czechia|Germany|Poland|Spain 1
United States|Spain 1

Sites per Study

Site_count Study_Count
1 90
2 4
3 3
4 1
5 5
6 4
9 4
10 1
12 3
13 1
20 1
23 1
25 1
26 1
30 1
32 2
33 1
34 1
46 1
50 1
66 1
69 1
91 1
106 1
110 1
160 1
363 1

Phase

Phase Study_Count
N/A 60
Phase 2 28
Phase 3 18
Phase 4 13
Phase 1/Phase 2 5
Phase 1 4
Phase 2/Phase 3 4
Early Phase 1 2

Number of Arms

Number_of_Arms Count_of_Studies
1 29
2 73
3 17
4 6
5 3
6 1
NA 5

Enrollment Metrics by Phase

Measure Early.Phase.1 N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 20 5.0000 16.00 10.0 14.00000 8.0 13.0000 3.0000
1st Qu. 25 20.7500 19.00 10.0 33.00000 20.0 88.7500 27.0000
Median 30 40.0000 34.50 15.0 70.00000 35.0 247.0000 52.0000
Mean 30 191.8833 41.25 22.4 86.60714 119.5 373.5556 194.6923
3rd Qu. 35 92.5000 56.75 35.0 100.25000 134.5 666.0000 126.0000
Max. 40 6800.0000 80.00 42.0 360.00000 400.0 1150.0000 1500.0000

Trial Group Type

group_type Group_Count
Experimental 149
Active Comparator 56
Placebo Comparator 33
Sham Comparator 19
Other 9
No Intervention 5
NA 5

Intervention Model

intervention_model Study_Count
Parallel Assignment 83
Single Group Assignment 34
Crossover Assignment 10
Factorial Assignment 3
Sequential Assignment 3
NA 1

Primary Purpose

primary_purpose Study_Count
Treatment 124
Basic Science 3
Other 3
Supportive Care 2
Device Feasibility 1
NA 1

Observational Studies

Studies by Country

Country Study_Count
United States 4
NA 3
Argentina|Brazil|Colombia|Mexico 1
Belgium|Germany|Italy|Netherlands|Portugal|Spain|United Kingdom 1
Germany 1
United Kingdom 1

Sites per Study

Site_count Study_Count
1 8
33 1
55 1
98 1

Enrollment Metrics

Measure Observational
Min 5.00
1st Qu 17.00
Median 50.00
Mean 19208.64
3rd Qu 1182.00
Max 200000.00

Observation Model

observational_model Study_Count
Cohort 6
Case-Only 2
Case Control 1
Other 1
NA 1

Time Perspective

time_perspective Study_Count
Prospective 6
Cross-Sectional 2
Retrospective 2
Other 1

Registries

Studies by Country

Country Study_Count
Austria|Belgium|Germany|United Kingdom 1
Canada 1
Poland 1

Sites per Study

Site_count Study_Count
1 2
16 1

Enrollment Metrics

Measure Registries
Min 40
1st Qu 80
Median 120
Mean 220
3rd Qu 310
Max 500

Registry Model

observational_model Study_Count
Cohort 2
Case-Control 1

Time Perspective

time_perspective Study_Count
Prospective 3

Follow-up

target_duration Study_Count
1 Month 1
1 Week 1
5 Years 1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id brief_title link overall_status source primary_completion_date
NCT03329391 Psychosocial Characteristics and Non-pharmacological Intervention of Patients With Treatment-resistant Depression https://ClinicalTrials.gov/show/NCT03329391 Recruiting National Taiwan University Hospital 2019-10-17
NCT03288675 Stepped Care aiTBS 2 Depression Study (Ghent) https://ClinicalTrials.gov/show/NCT03288675 Recruiting University Hospital, Ghent 2022-12-31
NCT03283670 Inhaled Nitrous Oxide for Treatment-Resistant Depression: Optimizing Dosing Strategies https://ClinicalTrials.gov/show/NCT03283670 Completed Washington University School of Medicine 2020-02-18
NCT03272698 ECT With Ketamine Anesthesia vs High Intensity Ketamine With ECT Rescue for Treatment-Resistant Depression https://ClinicalTrials.gov/show/NCT03272698 Recruiting University of Saskatchewan 2021-06-30
NCT03257397 TBS in Major Depression https://ClinicalTrials.gov/show/NCT03257397 Recruiting Medical University of Vienna 2020-07-31
NCT03240692 Stanford Accelerated Intelligent Neuromodulation Therapy for Treatment-Resistant Depression: OL Cohort https://ClinicalTrials.gov/show/NCT03240692 Active, not recruiting Stanford University 2020-05-01
NCT03191058 Confirmatory Efficacy and Safety Trial of Magnetic Seizure Therapy for Depression https://ClinicalTrials.gov/show/NCT03191058 Active, not recruiting University of Texas Southwestern Medical Center 2022-07-31
NCT03149991 A Study of Brexpiprazole Plus Ketamine in Treatment-Resistant Depression (TRD) https://ClinicalTrials.gov/show/NCT03149991 Completed Massachusetts General Hospital 2019-03-31
NCT03113968 ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD) https://ClinicalTrials.gov/show/NCT03113968 Active, not recruiting The Cleveland Clinic 2021-03-01
NCT03105700 Low Frequency TMS for Depression in Epilepsy https://ClinicalTrials.gov/show/NCT03105700 Recruiting Dartmouth-Hitchcock Medical Center 2020-10-31
NCT03068715 Stanford Accelerated Intelligent Neuromodulation Therapy for Treatment-Resistant Depression (SAINT-TRD) https://ClinicalTrials.gov/show/NCT03068715 Active, not recruiting Stanford University 2020-01-25
NCT03051256 Safety, Tolerability, PK Profile, and Symptom Response of a 7-Day Dosing With 25 mg Daily and 50 mg Daily of REL-1017 in Major Depressive Disorder https://ClinicalTrials.gov/show/NCT03051256 Completed Relmada Therapeutics, Inc. 2019-07-29
NCT03027362 Cognitive Therapy to Sustain the Antidepressant Effects of Intravenous Ketamine in Treatment-resistant Depression https://ClinicalTrials.gov/show/NCT03027362 Completed Yale University 2019-09-30
NCT03004521 Lithium Versus Quetiapine in Treatment Resistant Depression https://ClinicalTrials.gov/show/NCT03004521 Recruiting King’s College London 2020-07-31
NCT02994433 NMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain Circuits https://ClinicalTrials.gov/show/NCT02994433 Active, not recruiting Washington University School of Medicine 2020-08-31
NCT02974296 Neuroimaging in Patients Undergoing TMS for Depression https://ClinicalTrials.gov/show/NCT02974296 Completed New York State Psychiatric Institute 2019-08-20
NCT02971150 Treatment Resistant Depression and Insomnia in Older Veterans https://ClinicalTrials.gov/show/NCT02971150 Completed VA Pittsburgh Healthcare System 2017-03-31
NCT02960763 Optimizing Outcomes of Treatment-Resistant Depression in Older Adults https://ClinicalTrials.gov/show/NCT02960763 Active, not recruiting Washington University School of Medicine 2021-09-30
NCT02942368 Adaptive tDCS for Treatment-Resistant MDD https://ClinicalTrials.gov/show/NCT02942368 Active, not recruiting Washington University School of Medicine 2021-06-30
NCT02935595 Low Dose Intravenous Ketamine in Treatment Resistant Depression Patients https://ClinicalTrials.gov/show/NCT02935595 Active, not recruiting The University of Texas Health Science Center, Houston 2019-09-30
NCT02922725 Placebo-controlled Trial of 5-hydroxytryptophan and Creatine for SSRI or SNRI Augmentation in Treatment Resistant Depression in Females https://ClinicalTrials.gov/show/NCT02922725 Recruiting University of Utah 2020-07-31
NCT02918318 A Study to Evaluate the Efficacy, Safety and Tolerability of Fixed Doses of Intranasal Esketamine in Japanese Participants With Treatment Resistant Depression https://ClinicalTrials.gov/show/NCT02918318 Completed Janssen Pharmaceutical K.K. 2019-08-19
NCT02914769 Antidepressant Effects of Ayahuasca: a Randomized Placebo Controlled Trial in Treatment Resistant Depression https://ClinicalTrials.gov/show/NCT02914769 Completed Universidade Federal do Rio Grande do Norte 2016-12-31
NCT02911597 Double-Blind Trial of Ketamine Therapy Plus or Minus Naltrexone in Treatment Resistant Depression (TRD) https://ClinicalTrials.gov/show/NCT02911597 Completed Stanford University 2018-02-28
NCT02900092 Augmentation of Treatment-Resistant Depression With An Analog of the Neuroactive Steroid Allopregnanolone https://ClinicalTrials.gov/show/NCT02900092 Completed Massachusetts General Hospital 2018-01-12
NCT02810717 Effects of TBS on 5-HT1A Receptor Binding https://ClinicalTrials.gov/show/NCT02810717 Recruiting Medical University of Vienna 2019-11-30
NCT02782104 A Long-term Safety Study of Esketamine Nasal Spray in Treatment-resistant Depression https://ClinicalTrials.gov/show/NCT02782104 Recruiting Janssen Research & Development, LLC 2021-08-06
NCT02611206 Repetitive Transcranial Magnetic Stimulation for Adolescent Depression: Efficacy, Predictive Biomarkers, and Mechanisms https://ClinicalTrials.gov/show/NCT02611206 Recruiting University of Minnesota 2020-06-30
NCT02577250 Ketamine Infusions for PTSD and Treatment-Resistant Depression https://ClinicalTrials.gov/show/NCT02577250 Completed Minneapolis Veterans Affairs Medical Center 2016-06-30
NCT02522377 Administration of Subanesthetic Dose of Ketamine and Electroconvulsive Treatment for Treatment Resistant Depression https://ClinicalTrials.gov/show/NCT02522377 Completed The Cleveland Clinic 2018-03-01
NCT02497287 A Long-term, Safety and Efficacy Study of Intranasal Esketamine in Treatment-resistant Depression https://ClinicalTrials.gov/show/NCT02497287 Completed Janssen Research & Development, LLC 2017-10-28
NCT02493868 A Study of Intranasal Esketamine Plus an Oral Antidepressant for Relapse Prevention in Adult Participants With Treatment-resistant Depression https://ClinicalTrials.gov/show/NCT02493868 Completed Janssen Research & Development, LLC 2018-02-15
NCT02456948 Adjunct Minocyline in Treatment-resistant Depression https://ClinicalTrials.gov/show/NCT02456948 Active, not recruiting Charite University, Berlin, Germany 2020-02-29
NCT02452892 Low Field Magnetic Stimulation (LFMS) in Subjects With Treatment-Resistant Depression (TRD) https://ClinicalTrials.gov/show/NCT02452892 Completed Tal Medical, Inc. 2016-09-30
NCT02422186 A Study to Evaluate the Efficacy, Safety, and Tolerability of Intranasal Esketamine Plus an Oral Antidepressant in Elderly Participants With Treatment-resistant Depression https://ClinicalTrials.gov/show/NCT02422186 Completed Janssen Research & Development, LLC 2017-08-10
NCT02418585 A Study to Evaluate the Efficacy, Safety, and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant Depression https://ClinicalTrials.gov/show/NCT02418585 Completed Janssen Research & Development, LLC 2017-06-01
NCT02417064 A Study to Evaluate the Efficacy, Safety, and Tolerability of Fixed Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant Depression https://ClinicalTrials.gov/show/NCT02417064 Completed Janssen Research & Development, LLC 2018-02-20
NCT02360280 Efficacy of Repeated Ketamine Infusions for Treatment-resistant Depression https://ClinicalTrials.gov/show/NCT02360280 Completed VA Office of Research and Development 2018-10-22
NCT02356107 5-hydroxytryptophan and Creatine for Treatment Resistant Depression Associated With Hypoxia in Females https://ClinicalTrials.gov/show/NCT02356107 Completed University of Utah 2016-08-31
NCT02263872 Minocycline as an Adjunct for the Treatment of Depressive Symptoms: Pilot Randomized Controlled Trial https://ClinicalTrials.gov/show/NCT02263872 Completed Pakistan Institute of Living and Learning 2016-06-30
NCT02153502 Efficacy, Safety, and Tolerability Study of AVP-786 as an Adjunctive Therapy in Patients With Major Depressive Disorder With an Inadequate Response to Antidepressant Treatment https://ClinicalTrials.gov/show/NCT02153502 Completed Avanir Pharmaceuticals 2016-02-29
NCT02150577 Implementation Trial of Evidence Based Practices for Mood Disorders https://ClinicalTrials.gov/show/NCT02150577 Completed University of Arkansas 2017-11-01
NCT02141776 Comparison of Anodal Transcranial Direct Current Stimulation (t-DCS) and Sham Stimulation in Patients With Treatment-resistant Depression https://ClinicalTrials.gov/show/NCT02141776 Completed University of Florida 2018-01-08
NCT02080507 rTMS in Treatment Resistant Depression https://ClinicalTrials.gov/show/NCT02080507 Completed Emory University 2015-12-31
NCT02078817 Ketamine in Adolescents With Treatment-Resistant Depression https://ClinicalTrials.gov/show/NCT02078817 Completed University of Minnesota 2018-03-31
NCT01304147 Intranasal Ketamine in Treatment-Resistant Depression https://ClinicalTrials.gov/show/NCT01304147 Completed Icahn School of Medicine at Mount Sinai 2014-10-31
NCT01282632 Risperidone vs. Olanzapine as add-on Treatment in Treatment Resistant Depression https://ClinicalTrials.gov/show/NCT01282632 Completed Sunnybrook Health Sciences Centre 2004-03-31
NCT02046330 Deep Brain Stimulation (DBS) Therapy for Treatment Resistant Depression https://ClinicalTrials.gov/show/NCT02046330 Recruiting The University of Texas Health Science Center, Houston 2022-11-30
NCT02556606 Ketamine for Treatment Resistant Late-Life Depression https://ClinicalTrials.gov/show/NCT02556606 Active, not recruiting VA Office of Research and Development 2020-03-31
NCT01998958 A Study to Evaluate the Safety and Efficacy of Intranasal Esketamine in Treatment-resistant Depression https://ClinicalTrials.gov/show/NCT01998958 Completed Janssen Research & Development, LLC 2015-07-21
NCT01984710 DBS for TRD Medtronic Activa PC+S https://ClinicalTrials.gov/show/NCT01984710 Active, not recruiting Emory University 2023-09-30
NCT01983904 DBS for Treatment Resistant Depression https://ClinicalTrials.gov/show/NCT01983904 Completed University of Calgary 2017-12-31
NCT01973478 Deep Brain Stimulation in Patients With Chronic Treatment Resistant Depression https://ClinicalTrials.gov/show/NCT01973478 Completed Rennes University Hospital 2017-07-03
NCT01945047 Action of Ketamine in Treatment-Resistant Depression https://ClinicalTrials.gov/show/NCT01945047 Completed University of Ottawa 2017-12-31
NCT01944644 Low Field Magnetic Stimulation for Treatment Resistant Depression https://ClinicalTrials.gov/show/NCT01944644 Completed Weill Medical College of Cornell University 2016-05-31
NCT01935115 Comparing Ketamine and Propofol Anesthesia for Electroconvulsive Therapy https://ClinicalTrials.gov/show/NCT01935115 Completed University of Saskatchewan 2016-03-31
NCT01920555 Double-Blind, Placebo-Controlled Trial of Ketamine Therapy in Treatment-Resistant Depression (TRD) https://ClinicalTrials.gov/show/NCT01920555 Completed Massachusetts General Hospital 2017-01-31
NCT01898429 Deep Brain Stimulation (DBS) for Treatment-Resistant Depression (TRD) https://ClinicalTrials.gov/show/NCT01898429 Completed Dartmouth-Hitchcock Medical Center 2016-12-31
NCT01880593 Ketamine Plus Lithium in Treatment-Resistant Depression https://ClinicalTrials.gov/show/NCT01880593 Completed Icahn School of Medicine at Mount Sinai 2016-11-30
NCT01798407 DBS of the Lateral Habenula in Treatment-Resistant Depression https://ClinicalTrials.gov/show/NCT01798407 Active, not recruiting Baylor College of Medicine 2020-08-31
NCT01677078 Coupling Repetitive Transcranial Magnetic Stimulation With a Neuronavigation System in Treatment Resistant Depression https://ClinicalTrials.gov/show/NCT01677078 Completed Rennes University Hospital 2017-03-25
NCT01654796 Trial of Low Field Magnetic Stimulation Augmentation of Antidepressant Therapy in Treatment-Resistant Depression https://ClinicalTrials.gov/show/NCT01654796 Completed Massachusetts General Hospital 2016-05-31
NCT01640080 A Study of the Efficacy of Intravenous Esketamine in Adult Patients With Treatment-Resistant Depression https://ClinicalTrials.gov/show/NCT01640080 Completed Janssen Research & Development, LLC 2013-06-03
NCT01597167 Magnesium Sulfate Versus 5% Dextrose With Treatment Resistant Depression https://ClinicalTrials.gov/show/NCT01597167 Completed University of Miami 2014-12-31
NCT01596608 Magnetic Seizure Therapy (MST) for Treatment Resistant Depression, Schizophrenia, and Obsessive Compulsive Disorder https://ClinicalTrials.gov/show/NCT01596608 Completed Centre for Addiction and Mental Health 2019-06-30
NCT01515215 Repetitive Transcranial Magnetic Stimulation (rTMS) for Treatment Resistant Depressive Disorder https://ClinicalTrials.gov/show/NCT01515215 Completed Centre for Addiction and Mental Health 2016-10-31
NCT01507155 An Open Label Study of Clinical Utility and Patient Outcomes of the Genecept Assay https://ClinicalTrials.gov/show/NCT01507155 Completed Genomind, LLC 2014-05-31
NCT01407575 Buprenorphine for Treatment Resistant Depression https://ClinicalTrials.gov/show/NCT01407575 Completed University of Pittsburgh 2013-08-31
NCT01383811 Exercise in Treatment Resistant Depression (TRD): A Feasibility Study https://ClinicalTrials.gov/show/NCT01383811 Completed Milton S. Hershey Medical Center 2013-06-30
NCT01353092 Pulsating ElectroMagnetive Treatment (PEMF) at Treatment Resistant Depression https://ClinicalTrials.gov/show/NCT01353092 Completed Hillerod Hospital, Denmark 2013-06-30
NCT04428099 Healthy Lifestyle Promotion as Adjunctive Teletherapy for Treatment-resistant Major Depression https://ClinicalTrials.gov/show/NCT04428099 Recruiting University of the Balearic Islands 2022-01-12
NCT04226352 Three Dosing Regimens of Dextromethorphan (DXM) Reportedly Used in Major Depressive Disorder https://ClinicalTrials.gov/show/NCT04226352 Recruiting Johns Hopkins University 2020-12-31
NCT04216888 Biomarkers of Response to Ketamine in Depression: MRI and Blood Assays Before and After Open Label Intranasal Ketamine https://ClinicalTrials.gov/show/NCT04216888 Recruiting Nathan Kline Institute for Psychiatric Research 2020-06-30
NCT04202770 Focused Ultrasound and Exosomes to Treat Depression, Anxiety, and Dementias https://ClinicalTrials.gov/show/NCT04202770 Enrolling by invitation Neurological Associates of West Los Angeles 2021-12-31
NCT04199143 Brain Reactivity to Nitrous Oxyde in Depression : an MRI and Ultrasound Study (PROTOBRAIN Pilote) https://ClinicalTrials.gov/show/NCT04199143 Recruiting University Hospital, Tours 2021-09-30
NCT04159285 Psychotherapeutic Augmentation of Brain Stimulation Effects https://ClinicalTrials.gov/show/NCT04159285 Recruiting Charite University, Berlin, Germany 2020-06-15
NCT04153812 Clinical Study on the Safety and Effectiveness of Vagus Nerve Stimulation in the Treatment of Refractory Depression https://ClinicalTrials.gov/show/NCT04153812 Recruiting Xijing Hospital 2021-10-01
NCT04106466 DBS for TRD With the Medtronic Summit RC+S https://ClinicalTrials.gov/show/NCT04106466 Active, not recruiting Icahn School of Medicine at Mount Sinai 2023-12-31
NCT04076124 Brain-derived Neurotrophic Factor and the Antidepressant Efficacy of Brain Stimulation https://ClinicalTrials.gov/show/NCT04076124 Recruiting Taipei Veterans General Hospital, Taiwan 2021-09-30
NCT04039022 Open-Label Safety Study of AXS-05 in Subjects With Depression https://ClinicalTrials.gov/show/NCT04039022 Recruiting Axsome Therapeutics, Inc. 2020-07-31
NCT04037592 Dorsomedial Prefrontal Cortex and the Antidepressant Efficacy of Theta Burst Stimulation in Depressed Patients https://ClinicalTrials.gov/show/NCT04037592 Recruiting Taipei Veterans General Hospital, Taiwan 2020-12-31
NCT04009928 Deep Brain Stimulation for Treatment Resistant Depression https://ClinicalTrials.gov/show/NCT04009928 Recruiting Sunnybrook Health Sciences Centre 2022-01-31
NCT03991572 rTMS Intervention on Motivational Anhedonia of Treatment Resistant Depression and Brian Network Mechanism https://ClinicalTrials.gov/show/NCT03991572 Recruiting Anhui Medical University 2021-12-31
NCT03965858 Efficacy, Safety and Pharmacokinetic Study of Inhaled Esketamine in Treatment-resistant Depression https://ClinicalTrials.gov/show/NCT03965858 Completed Celon Pharma SA 2020-03-15
NCT03952962 Tractography Guided Subcallosal Cingulate Deep Brain Stimulation for Treatment Resistant Depression https://ClinicalTrials.gov/show/NCT03952962 Recruiting University of California, Los Angeles 2024-07-31
NCT03932825 Nitrous Oxide for Major Depressive Disorder https://ClinicalTrials.gov/show/NCT03932825 Recruiting Central South University 2020-08-31
NCT03887715 A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression https://ClinicalTrials.gov/show/NCT03887715 Recruiting LivaNova 2022-08-31
NCT03887624 Investigate the Clinical Responses of Ethosuximide in Patients With Treatment-Resistant Depression. https://ClinicalTrials.gov/show/NCT03887624 Recruiting Zhejiang University 2020-04-30
NCT03786614 Antidepressant Discontinuation in Treatment Resistant Depression https://ClinicalTrials.gov/show/NCT03786614 Recruiting University of Louisville 2021-04-30
NCT03775200 The Safety and Efficacy of Psilocybin in Participants With Treatment Resistant Depression https://ClinicalTrials.gov/show/NCT03775200 Recruiting COMPASS Pathways 2020-08-31
NCT03756129 Proof of Concept Study Evaluating the Efficacy and Safety of MIJ821 in Patients With Treatment-resistant Depression https://ClinicalTrials.gov/show/NCT03756129 Completed Novartis 2020-03-23
NCT03742557 Evaluation of Schemes of Administration of Intravenous Ketamine in Depression https://ClinicalTrials.gov/show/NCT03742557 Recruiting National Institute of Neurology and Neurosurgery, Mexico 2020-01-01
NCT03701724 Cost-utility Analysis of Maintenance rTMS for Treatment-resistant Depression https://ClinicalTrials.gov/show/NCT03701724 Recruiting Nantes University Hospital 2021-10-15
NCT03684447 Neural and Antidepressant Effects of Propofol https://ClinicalTrials.gov/show/NCT03684447 Recruiting University of Utah 2024-03-31
NCT03680781 Accelerated Theta Burst in Treatment-Resistant Depression: A Dose Finding and Biomarker Study https://ClinicalTrials.gov/show/NCT03680781 Enrolling by invitation Stanford University 2022-12-31
NCT03653858 Efficacy Study of Deep Brain Stimulation in Patients With Treatment Resistant Major Depression https://ClinicalTrials.gov/show/NCT03653858 Recruiting University Hospital Freiburg 2022-06-02
NCT03642522 Investigating Predictors of Treatment Response in Treatment-Resistant Depression (TRD) With Interleaved TMS/fMRI https://ClinicalTrials.gov/show/NCT03642522 Recruiting University of British Columbia 2019-12-31
NCT03626181 Biomarkers of Theta Burst Stimulation in Major Depressive Disorder https://ClinicalTrials.gov/show/NCT03626181 Recruiting University of Calgary 2019-07-01
NCT03606395 Safety, Tolerability, PK and Efficacy of Single Doses of NV-5138 in Healthy Volunteers and Subjects With Treatment-Resistant Depression https://ClinicalTrials.gov/show/NCT03606395 Completed Navitor Pharmaceuticals, Inc. 2019-06-09
NCT03573349 Glutamate MRS During Ketamine Infusion https://ClinicalTrials.gov/show/NCT03573349 Enrolling by invitation Mayo Clinic 2021-08-31
NCT03564041 SSM vs HEP in Late-Life Depression https://ClinicalTrials.gov/show/NCT03564041 Recruiting Lawson Health Research Institute 2021-08-31
NCT03435744 Simvastatin as an Augmentation Treatment for Treatment Resistant Depression: Randomized Controlled Trial. https://ClinicalTrials.gov/show/NCT03435744 Recruiting Pakistan Institute of Living and Learning 2020-12-31
NCT03434041 A Study to Evaluate the Efficacy, Pharmacokinetics, Safety and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant Depression https://ClinicalTrials.gov/show/NCT03434041 Recruiting Janssen Research & Development, LLC 2021-04-28
NCT03428828 Neurofeedback for Treatment Resistant Depression https://ClinicalTrials.gov/show/NCT03428828 Recruiting University of Pittsburgh 2023-03-01
NCT01246908 Efficacy, Safety and Tolerability of CX157 in Treatment Resistant Depression https://ClinicalTrials.gov/show/NCT01246908 Completed CeNeRx BioPharma Inc. 2012-05-31
NCT01204918 Efficacy and Tolerability of Riluzole in Treatment Resistant Depression https://ClinicalTrials.gov/show/NCT01204918 Completed Yale University 2015-05-31
NCT01179009 Treatment Resistant Depression (Pilot) https://ClinicalTrials.gov/show/NCT01179009 Active, not recruiting Washington University School of Medicine 2020-06-30
NCT01071538 Buprenorphine for Late-Life Treatment Resistant Depression https://ClinicalTrials.gov/show/NCT01071538 Completed University of Pittsburgh 2012-05-31
NCT00958568 A Study in Relapse Prevention of Treatment-Resistant Depression https://ClinicalTrials.gov/show/NCT00958568 Completed Eli Lilly and Company 2012-03-31
NCT00953745 Dopaminergic Effects of Adjunctive Aripiprazole on the Brain in Treatment-Resistant Depression https://ClinicalTrials.gov/show/NCT00953745 Completed Washington University School of Medicine 2012-06-30
NCT00837486 Reclaim Deep Brain Stimulation Clinical Study for Treatment-Resistant Depression https://ClinicalTrials.gov/show/NCT00837486 Completed MedtronicNeuro 2010-12-31
NCT03711019 Efficacy of Convulsive Therapies During Continuation https://ClinicalTrials.gov/show/NCT03711019 Recruiting Centre for Addiction and Mental Health 2021-09-30
NCT03152409 Salicylic Augmentation in Depression https://ClinicalTrials.gov/show/NCT03152409 Recruiting Brigham and Women’s Hospital 2020-07-31
NCT00809562 A Study of RO4917523 in Patients With Treatment Resistant Depression https://ClinicalTrials.gov/show/NCT00809562 Completed Hoffmann-La Roche 2011-02-28
NCT00808938 A Pilot Study of the Use of Magnetic Seizure Therapy for Depression https://ClinicalTrials.gov/show/NCT00808938 Completed Bayside Health 2011-01-31
NCT01627782 A Study of Ketamine in Patients With Treatment-resistant Depression https://ClinicalTrials.gov/show/NCT01627782 Completed Janssen Research & Development, LLC 2013-09-12
NCT03953417 Bilateral Accelerated Theta Burst in Treatment-Resistant Bipolar Depression https://ClinicalTrials.gov/show/NCT03953417 Recruiting Stanford University 2021-07-01
NCT00789854 Comparing Quetiapine XR Monotherapy and Augmentation With Lithium Augmentation in TRD Patients https://ClinicalTrials.gov/show/NCT00789854 Completed AstraZeneca 2009-08-31
NCT00768430 Optimization of IV Ketamine for Treatment Resistant Depression https://ClinicalTrials.gov/show/NCT00768430 Completed Baylor College of Medicine 2012-09-30
NCT00704860 Treatment-Resistant Depression, Hippocampus Atrophy and Serotonin Genetic Polymorphism https://ClinicalTrials.gov/show/NCT00704860 Completed University of Ottawa 2009-11-30
NCT00667680 Transcranial Direct Current Stimulation (tDCS) in Treatment-resistant Depression https://ClinicalTrials.gov/show/NCT00667680 Completed Ludwig-Maximilians - University of Munich 2008-09-30
NCT00664976 Treatment Resistant Depression in Bipolar Disorder - A Randomized Controlled Trial of Electroconvulsive Therapy https://ClinicalTrials.gov/show/NCT00664976 Completed Norwegian University of Science and Technology 2011-05-31
NCT00608543 Aripiprazole Augmentation of SSRI Therapy in Treatment Refractory Depression https://ClinicalTrials.gov/show/NCT00608543 Completed University of Texas Southwestern Medical Center 2009-01-31
NCT00565617 Epidural Cortical Stimulation for Depression https://ClinicalTrials.gov/show/NCT00565617 Active, not recruiting Medical University of South Carolina 2009-12-31
NCT00531726 Berlin Deep Brain Stimulation Depression Study https://ClinicalTrials.gov/show/NCT00531726 Completed Charite University, Berlin, Germany 2012-09-30
NCT00367003 Deep Brain Stimulation for Treatment Resistant Depression https://ClinicalTrials.gov/show/NCT00367003 Recruiting Emory University 2024-11-30
NCT00305565 Study Comparing Outcomes for Patients With Treatment Resistant Depression Who Receive VNS Therapy at Different Doses https://ClinicalTrials.gov/show/NCT00305565 Completed Cyberonics, Inc. 2010-02-28
NCT00253266 Venlafaxine Augmentation in Treatment Resistant Depression https://ClinicalTrials.gov/show/NCT00253266 Completed Max-Planck-Institute of Psychiatry 2014-04-30
NCT00186056 Mifepristone in Refractory Depression https://ClinicalTrials.gov/show/NCT00186056 Completed Stanford University 2007-05-31
NCT00179244 Risperidone vs. Bupropion ER Augmentation of SSRIs in Treatment-Resistant Depression https://ClinicalTrials.gov/show/NCT00179244 Completed Vanderbilt University NA
NCT00093847 Optimizing the Effectiveness of Selective Serotonin Reuptake Inhibitors (SSRIs) in Treatment-Resistant Depression https://ClinicalTrials.gov/show/NCT00093847 Completed Massachusetts General Hospital 2009-02-28
NCT00070694 An Investigation of the Antidepressant Efficacy of the 5-HT2A Antagonist, M100907, in Combination With Citalopram in Treatment Resistant Depression https://ClinicalTrials.gov/show/NCT00070694 Completed National Institutes of Health Clinical Center (CC) NA
NCT00044681 A Study of the Effectiveness and Safety of Risperidone to Augment SSRI Therapy in Patients With Treatment-resistant Depression https://ClinicalTrials.gov/show/NCT00044681 Completed Johnson & Johnson Pharmaceutical Research & Development, L.L.C. NA
NCT00035321 The Study of Olanzapine Plus Fluoxetine in Combination for Treatment of Treatment Resistant Depression https://ClinicalTrials.gov/show/NCT00035321 Completed Eli Lilly and Company NA

Observational Studiess

#If less then 500 studies

nct_id brief_title link overall_status source primary_completion_date
NCT03373253 Treatment-Resistant Depression Cohort in Europe https://ClinicalTrials.gov/show/NCT03373253 Completed Janssen-Cilag Ltd. 2020-01-24
NCT03360942 Long Term Follow-up of Deep Brain Stimulation for Treatment-Resistant Depression https://ClinicalTrials.gov/show/NCT03360942 Active, not recruiting Dartmouth-Hitchcock Medical Center 2026-11-22
NCT03207282 Treatment Resistant Depression in America Latina https://ClinicalTrials.gov/show/NCT03207282 Completed Janssen-Cilag, S.A. 2019-11-25
NCT03134066 Neurocognitive Features of Patients With Treatment-Resistant Depression https://ClinicalTrials.gov/show/NCT03134066 Completed Massachusetts General Hospital 2017-08-09
NCT03109002 An Epidemiology Study of Treatment Resistant Depression in the United States (US) https://ClinicalTrials.gov/show/NCT03109002 Completed Janssen Research & Development, LLC 2017-05-18
NCT02691520 Epidemiology of Treatment Resistant Depression in Taiwan https://ClinicalTrials.gov/show/NCT02691520 Completed Johnson & Johnson Pte Ltd 2016-02-29
NCT04021823 Neurobiological Analyses Within the FORESEE III Study https://ClinicalTrials.gov/show/NCT04021823 Recruiting University Hospital Freiburg 2022-06-30
NCT03851380 Improving Brain Stimulation Through Imaging https://ClinicalTrials.gov/show/NCT03851380 Recruiting VA Office of Research and Development 2023-03-31
NCT01162434 Brain MRI (Magnetic Resonance Imaging) Scans of Patients With Treatment Resistant Depression (TRD) and Healthy Controls https://ClinicalTrials.gov/show/NCT01162434 Completed University of Bristol 2012-02-29
NCT03109717 Structural and Functional Connectivity of Brainstem Monoamine Pathways in Treatment Resistant Depression https://ClinicalTrials.gov/show/NCT03109717 Active, not recruiting The Cleveland Clinic 2020-11-30
NCT00320372 Treatment-Resistant Depression Registry https://ClinicalTrials.gov/show/NCT00320372 Completed Cyberonics, Inc. 2015-03-31

Registries

#If less then 500 registries

nct_id brief_title link overall_status source primary_completion_date
NCT03320304 A Study to Assess Effectiveness and Efficiency of VNS Therapy in Patients With Difficult to Treat Depression. https://ClinicalTrials.gov/show/NCT03320304 Recruiting LivaNova 2023-12-01
NCT04226963 A Naturalistic Study of Ketamine for Treatment Resistant Mood Disorders https://ClinicalTrials.gov/show/NCT04226963 Recruiting Medical University of Gdansk 2022-12-31
NCT03977038 Investigation of the Effects of Repetitive Transcranial Magnetic Stimulation on Cognition in Depression https://ClinicalTrials.gov/show/NCT03977038 Recruiting Sunnybrook Health Sciences Centre 2020-04-30